Things we like to do
Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome
Månsson, K. N. T., Waschke, L., Manzouri, A., Furmark, T., Fischer, H., & Garrett, D. D. (2022). Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2021.09.026
Presentation on YouTube, click here!
Cover art: The cover art is an illustration of how moment-to-moment brain signal variability differs across individuals. In this issue, Månsson et al. demonstrate that such individual differences in brain signal variability formed a reliable and accurate predictor of treatment success in patients with social anxiety disorder receiving cognitive behavioral therapy. The cover was art directed by Heejung Jung (Department of Psychological and Brain Sciences, Dartmouth College) and graphical design was executed by Kristoffer N. T. Månsson (Department of Clinical Neuroscience, Karolinska Institutet).
Honorable Mention from Biological Psychiatry's Somerfeld-Ziskind Research Award
We are very honored to be short-listed for the 2023 Somerfeld-Ziskind Research Award. Thanks!
Månsson, K. N. T., Waschke, L., Manzouri, A., Furmark, T., Fischer, H., & Garrett, D. D. (2022). Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2021.09.026
Investigate rapid brain plasticity using structural magnetic resonance imaging
Cellular protection and biological aging in social anxiety disordered patients receiving cognitive-behavioral therapy (CBT)
Latest news from the lab
Funding to study humans and zebrafish
2022.10.14: New grant. Dr Månsson and Dr Ampatzis received funding from KIRI Fellow "Investigations of brain signal variability and rapid plasticity during approach-avoidance of fear: experiments of humans and zebrafish". Postdoc position will soon be announced!
New grant from the Swedish Brain Foundation (Hjärnfonden)
2022.07.04: New grant. Dr Månsson received 600.000 SEK from the Swedish Brain Foundation for a project entitled "Placebo response in cognitive behavior therapy: An experimental study on expectations in social anxiety disorder". Thanks to Hjärnfonden!
2.4 MSEK to investigate psychiatric patients' neural variability
2022.06.27: New grant. Dr Månsson was awarded 2.400.000 SEK for a study aiming at "Predicting cognitive behavior therapy outcome with patients’ expectations and neural variability". We look forward to continue our collaborative efforts with Region Stockholm health care and Internetpsykiatri at campus Flemingsbergs. Thanks to CIMED and Region Stockholm!
Associate Professor (Docent)
2022.05.24: Docent. After external review and decision by Docentutskottet at Karolinska Institutet, Kristoffer Månsson is appointed as Docent (Associate Professor).
Prize at StratNeuro Retreat
2022.05.20 At the StratNeuro Retreat 2022 (more info here), Dr Månsson was awarded the best clinical/translational poster.
KIRI Fellow
2022.04.22: KIRI Fellow. Dr Månsson is a KIRI Fellow 2022. Karolinska Institutet's Research Incubator (KIRI) is a research forum in which a new generation of researchers can collaborate and develop joint interdisciplinary research projects in a unique interdisciplinary environment. Click here to read more!
Gray matter volume changes after 2 minutes of finger tapping?
2022.02.08: New paper out. Estimated gray matter volume rapidly changes after a short motor task. Read paper, click here!
Paper out in Biological Psychiatry
2021.10.11: New paper out. Biological Psychiatry: Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. The article is available for free, click here!
A short YouTube on the paper, here!
Assistant Professor in medical science
2021.02.18: New grant and academic position. Exciting times ahead! Dr Månsson is awarded a position as Assistant Professor in medical science at Karolinska Institutet (starting 2022). The position includes research funding for 6 years, click here for more information.
Lab members
Kristoffer N T Månsson, PhD
Principal investigator, Associate Professor
Previous academic positions
Nikolay Popov, MSc
PhD student
Nikolay completed a BSc in Economics at Higher School of Economics, Moscow, Russia, and a MSc in Engineering at Nara Institute of Science and Technology, Nara, Japan, before joining the lab as a PhD student. Methodologically, Nikolay will focus on brain signal variability and extracting dynamic brain states from functional magnetic resonance imaging (fMRI) data to investigate the brain of patients with social anxiety disorder and/or major depressive disorder. Nikolay will also closely work on experimental designs involving naturalistic fMRI tasks.
Tuğçe Yıldız, MSc
PhD student
Tuğçe completed a BSc in psychology in Turkey, and MSc in Cognitive Neuroscience and Clinical Neuropsychology at Padova University, Italy, before joining the lab as a PhD student. Tuğçe will use a variety of scientific methods and analytic techniques to investigate the brain of patients with social anxiety disorder, including functional and structural magnetic resonance imaging (MRI), and magnetoencephalography (MEG). For instance, Tuğçe will investigate brain signal variability and signal complexity, as well as gray matter volume in patients with social anxiety disorder.
Karen Kuckelkorn, MSc
PTP-psykolog (clinical psychologist under training)
Karen completed a BSc and MSs degree in psychology (Brain & Cognition) at the University of Amsterdam (The Netherlands), and also completed supplementary education in clinical psychology at Umeå University (Sweden), before joining the lab as a clinical psychologist under training (PTP). Karen will focus on how patients' expectations affect cognitive-behavioural therapy outcomes for social anxiety disorder by using self-rated questionnaires and functional magnetic resonance imaging (fMRI). Karen will be involved in a fMRI study using a balanced placebo design in order to manipulate patients' expectations.
Amir Manzouri, MSc
Research engineer
Amir studied medical imaging at the Royal Institute of Technology in Stockholm and has been working with neuroimaging methods as a research engineer since 2010. Amir has been involved in research on Alzheimer’s disease, gender identity, emotion, stress and anxiety disorders. Amir has extensive experience with data collection (e.g., magnetic resonance imaging, MRI scanning), and expertise in data pre- and post-processing, higher level statistical analyses on functional MRI data, e.g., psycho-physiological interactions (PPI), partial least squares (PLS), support vector machines (SVM), and independent component analysis (ICA). Moreover, Amir also has extensive expertise in structural MRI data analysis, e.g., FreeSurfer, AFNI, BrainVoyager, and voxel based morphometry (VBM), and tract-based spatial statistics (TBSS).
Sylvia Edwards, MSc
Research assistant
Sylvia studied Art and Psychology in the UK before completing an MSc in Cognitive Neuroscience in the Netherlands. Sylvia will work as a research assistant on multiple projects, including collecting MRI data for a large twin study on stress responses (PI Professor Fredrik Åhs). Sylvia will also analyse fMRI and sleepiness data from individuals experiencing sleep deprivation.
Elise Björnelius
Research Assistant
Elise is a student at Psykologprogrammet (Master of Psychology), Stockholm University and a research assistant in the lab. Specifically, Elise is supporting the TreVar research project by coordinating information and participants recruited from a psychiatric clinic within Region Stockholm. Elise interview and schedule participants, assist other staff at the magnetic resonance imaging (MRI) scanner, as well as setting up a computerized experiment for our participants.
Marion Erlandsdotter
Research Assistant
Marion is a student at Psykologprogrammet (Master of Psychology), Stockholm University and a research assistant in the lab. Specifically, Marion is supporting the TreVar research project by coordinating information and participants recruited from a psychiatric clinic within Region Stockholm. Marion interview and schedule participants, assist other staff at the magnetic resonance imaging (MRI) scanner, as well as setting up a computerized experiment for our participants.
Liisbeth Pirn
Research Internship
Liisbeth is studying Bachelor of Psychology at the University of Munich (LMU) and is currently working on her bachelor thesis on neural activation patterns in different working memory tasks. She is doing a voluntary 6 month internship helping the lab with manual denoising of fMRI images and conducting fMRI experiments.
Alumni
Internships and Bachelor or Master level theses
Extended network and collaborations
A selection of ongoing collaborations with principal investigators
Collaborators
of selected publications
Scientific publications
Highlighted
Peer-reviewed
Funding sources
We are grateful for the generous support provided by
European Union
Funding provided by the European Union.
KIRI Fellow
Center for Innovative Medicine (CIMED)
Karolinska Institutet
Swedish Brain Foundation
Media presence
Our research in the media:
Scientific American
"Cognitive-behavioral therapy improved both symptoms and markers of senescence in people with anxiety" Click here to go to the Scientific American magazine
Forskning & Framsteg
Rätt hjärnmönster för en lyckad terapi. En undersökning av hjärnans aktivitet avslöjar hur patienten kommer att svara på behandling med KBT. Klicka här för att läsa artikeln
Psykologtidningen
Biologi och psykologi i förening kan bidra till effektivare och mer individanpassad psykologisk behandling. Ladda hem artikeln här
Contact details
Kristoffer Månsson
kristoffer.mansson@ki.se
Phone
+46 (0) 70 580 3267
Copyright 2023