Dr Månsson's Lab
Kristoffer N T Månsson, PhD
Things we like to do
Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome
Investigate rapid brain plasticity using structural magnetic resonance imaging
Cellular protection and biological aging in social anxiety disordered patients receiving cognitive-behavioral therapy (CBT)
Latest news from the lab
Funding from the Swedish Brain Foundation
2022.07.04: New grant. Dr Månsson was granted funding (600.000 SEK) from the Swedish Brain Foundation (Hjärnfonden) to study "Placebo response in cognitive behavior therapy: An experimental study on expectations in social anxiety disorder". Thanks for your generous support!
2.4 MSEK to investigate psychiatric patients' neural variability
2022.06.27: New grant. Dr Månsson was awarded 2.400.000 SEK for a study aiming at "Predicting cognitive behavior therapy outcome with patients’ expectations and neural variability". We look forward to continue our collaborative efforts with Region Stockholm health care and Internetpsykiatri at campus Flemingsbergs. Thanks to CIMED and Region Stockholm!
Associate Professor (Docent)
2022.05.24: Docent. After external review and decision by Docentutskottet at Karolinska Institutet, Kristoffer Månsson is appointed as Docent (Associate Professor).
Prize at StratNeuro Retreat
2022.05.20. Conference. At the StratNeuro Retreat 2022 (more info here), Dr Månsson was awarded the best clinical/translational poster.
KIRI Fellow
2022.04.22: KIRI Fellow. Dr Månsson is a KIRI Fellow 2022. Karolinska Institutet's Research Incubator (KIRI) is a research forum in which a new generation of researchers can collaborate and develop joint interdisciplinary research projects in a unique interdisciplinary environment. Click here to read more!
Gray matter volume changes after 2 minutes of finger tapping?
2022.02.08: New paper out. Estimated gray matter volume rapidly changes after a short motor task. Read paper, click here!
Paper out in Biological Psychiatry
2021.10.11: New paper out. Biological Psychiatry: Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. The article is available for free, click here!
A short YouTube on the paper, here!
Assistant Professor in medical science
2021.02.18: New grant and academic position. Exciting times ahead! Dr Månsson is awarded a position as Assistant Professor in medical science at Karolinska Institutet (starting 2022). The position includes research funding for 6 years, click here for more information.
Interested in joining us?
If you are a highly motivated student looking for an internship, position as research assistant, PhD student, or postdoctoral fellowship - don't hesitate to get in touch with us! kristoffer.mansson@ki.se
Internships open from January 2023
We can host internships for international students visiting the lab for a few months. Contact us for more information.
Lab members
Kristoffer N T Månsson, PhD
Principal investigator, Assistant Professor in Medical Science
Previous academic positions
Tuğçe Yıldız, MSc
PhD student
Tuğçe completed a BSc in psychology in Turkey, and MSc in Cognitive Neuroscience and Clinical Neuropsychology at Padova University, Italy, before joining the lab as a PhD student. Tuğçe will use a variety of scientific methods and analytic techniques to investigate the brain of patients with social anxiety disorder, including functional and structural magnetic resonance imaging (MRI), and magnetoencephalography (MEG). For instance, Tuğçe will investigate brain signal variability and signal complexity, as well as gray matter volume in patients with social anxiety disorder.
Amir Manzouri, MSc
Research engineer
Amir studied medical imaging at the Royal Institute of Technology in Stockholm and has been working with neuroimaging methods as a research engineer since 2010. Amir has been involved in research on Alzheimer’s disease, gender identity, emotion, stress and anxiety disorders. Amir has extensive experience with data collection (e.g., magnetic resonance imaging, MRI scanning), and expertise in data pre- and post-processing, higher level statistical analyses on functional MRI data, e.g., psycho-physiological interactions (PPI), partial least squares (PLS), support vector machines (SVM), and independent component analysis (ICA). Moreover, Amir also has extensive expertise in structural MRI data analysis, e.g., FreeSurfer, AFNI, BrainVoyager, and voxel based morphometry (VBM), and tract-based spatial statistics (TBSS).
Mathilda Björkman, MSc
Research Assistant/Intern Clinical Psychologist
Mathilda is a research assistant in the lab and is involved in fMRI scanning och scheduling participants to an ongoing data collection. Mathilda is also an intern clinical psychologist under supervision (PTP) in adult general psychiatry. Mathilda is involved in a project investigating socio-affective neural response to predict the outcome of internet-based CBT in adults with common psychiatric disorders. Mathilda’s master thesis is entitled “Predicting psychiatric patients’ symptom improvement after internet-delivered cognitive behavioral therapy”.
Alice Clerouin, BSc
Internship, France
Alice is an intern in the lab. She completed a BSc in biology and she is currently in her first year of MSc in Neurosciences in Paris, France. In the lab, Alice is manually denoising BOLD-fMRI data for a project on face-emotion recognition in a large twin study. The objective of the project is to investigate heritability of BOLD-fMRI variability during emotion recognition.
Katarzyna Karpa, BSc
Internship, Germany
Katarzyna is a Neuroscience Masters student from Heidelberg University, Germany, doing her lab rotation in the lab. Her background is in Molecular Biosciences. Katarzyna is manually denoising BOLD-fMRI data, and reviewing the literature on epigenetic variability in psychiatric disorders.
Sara Halmans, MSc
Internship, Germany
Sara completed a BSc and MSc in psychology in Germany before joining the lab as a research intern. During her internship, Sara will focus on manually denoising and analyzing fMRI data from the Stockholm Sleepy Brain study. She will investigate the signal variability of fMRI data in young and older adults, comparing a full sleep to sleep deprivation. Additionally, Sara will use the internship to improve her programming skills in an application-based manner.
Alumni
Theses (Bachelor or Master level theses)
Extended network and collaborations
A selection of ongoing collaborations with principal investigators
National collaborations
International collaborations
of selected publications
Scientific publications
Highlighted
Peer-reviewed
36. Jayaram-Lindström, N., Rozental, A., Sörman, K., Ojala, O., Jangard, S., El Alaoui, S., Månsson, K. N. T., Shahnavaz, S., Lundin, J., Forsström, D., Hedman-Lagerlöf, M., Lundgren, T. Mental Health in Individuals with Self-Reported Psychiatric Symptoms During the COVID-19 Pandemic: Baseline Data from a Swedish Longitudinal Cohort Study. Frontiers in Psychiatry, In press
35. Olivo, G., Lövdén, M., Manzouri, A., Terlau, L., Jenner, B., Jafari, A., Petersson, S., Li, T.-Q., Fischer, H., & Månsson, K. N. T. (2022). Estimated Gray Matter Volume Rapidly Changes after a Short Motor Task. Cerebral Cortex. https://doi.org/10.1093/cercor/bhab488
34. Kumar, P., Stiernborg, M., Fogdell-Hahn, A., Månsson, K. N. T., Furmark, T., Berglind, D., Melas, P. A., Forsell, Y., & Lavebratt, C. (2022). Physical exercise is associated with a reduction in plasma levels of fractalkine, TGF-β1, eotaxin-1 and IL-6 in younger adults with mobility disability. PloS One, 17(2), e0263173. https://doi.org/10.1371/journal.pone.0263173
33. Li, X., Fischer, H., Manzouri, A., Månsson, K. N. T., & Li, T.-Q. (2021). A Quantitative Data-Driven Analysis Framework for Resting-State Functional Magnetic Resonance Imaging: A Study of the Impact of Adult Age. Frontiers in Neuroscience, 15, 1392. https://doi.org/10.3389/fnins.2021.768418
32. Månsson, K. N. T., Waschke, L., Manzouri, A., Furmark, T., Fischer, H., & Garrett, D. D. (2021). Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2021.09.026
31. Månsson, K. N. T., Lasselin, J., Karshikoff, B., Axelsson, J., Engler, H., Schedlowski, M., Benson, S., Petrovic, P., & Lekander, M. (2021). Anterior insula morphology and vulnerability to psychopathology-related symptoms in response to acute inflammation. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2021.09.007
30. Hjorth, O., Frick, A., Gingnell, M., Motilla-Hoppe, J., Faria, V., Hultberg, S., Alaie, I., Månsson, K.N.T., Rosén, J., Reis, M., Wahlstedt, K., Jonasson, M., Lubberink, M., Antoni, G., Fredriksson, M., Furmark, T. Expectancy effects on serotonin and dopamine transporters during SSRI treatment of social anxiety disorder: A randomized clinical trial. Transl. Psychiatry. In press
29. Koenig, J., Abler, B., Agartz, I., Åkerstedt, T., Andreassen, O. A., Anthony, M., Bär, K.-J., Bertsch, K., Brown, R. C., Brunner, R., Carnevali, L., Critchley, H. D., Cullen, K. R., de Geus, E. J. C., de la Cruz, F., Dziobek, I., Ferger, M. D., Fischer, H., Flor, H., … Månsson, K. N. T., … Quintana, D. S. (2021). Cortical thickness and resting-state cardiac function across the lifespan: A cross-sectional pooled mega-analysis. Psychophysiology, 58(7), e13688. https://doi.org/10.1111/psyp.13688
28. Li, X., Fischer, H., Manzouri, A., Månsson, K. N. T., & Li, T.-Q. (2021). Dataset of whole-brain resting-state fMRI of 227 young and elderly adults acquired at 3T. Data in Brief, 38, 107333. https://doi.org/10.1016/j.dib.2021.107333
27. Månsson, K. N. T., Lueken, U., & Frick, A. (2021). Enriching CBT by Neuroscience: Novel Avenues to Achieve Personalized Treatments. International Journal of Cognitive Therapy, 14(1), 182–195. https://doi.org/10.1007/s41811-020-00089-0
26. Åkerstedt, T., Lekander, M., Nilsonne, G., Tamm, S., d’Onofrio, P., Kecklund, G., Fischer, H., Schwarz, J., Petrovic, P., & Månsson, K. N. T. (2020). Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults. Nature and Science of Sleep, 12, 289–298. https://doi.org/10.2147/NSS.S240493
25. Bas-Hoogendam, J. M., Groenewold, N. A., Aghajani, M., Freitag, G. F., Harrewijn, A., Hilbert, K., Jahanshad, N., Thomopoulos, S. I., Thompson, P. M., Veltman, D. J., Winkler, A. M., Lueken, U., Pine, D. S., van der Wee, N. J. A., Stein, D. J., & ENIGMA-Anxiety Working Group. (2020). ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders. Human Brain Mapping, hbm.25100. https://doi.org/10.1002/hbm.25100
24. Costache, M. E., Frick, A., Månsson, K. N. T., Engman, J., Faria, V., Hjorth, O., Hoppe, J. M., Gingnell, M., Frans, Ö., Björkstrand, J., Rosén, J., Alaie, I., Åhs, F., Linnman, C., Wahlstedt, K., Tillfors, M., Marteinsdottir, I., Fredrikson, M., & Furmark, T. (2020). Higher- and lower-order personality traits and cluster subtypes in social anxiety disorder. PloS One, 15(4), e0232187. https://doi.org/10.1371/journal.pone.0232187
23. Kraepelien, M., Schibbye, R., Månsson, K. N. T., Sundström, C., Riggare, S., Andersson, G., Lindefors, N., Svenningsson, P., & Kaldo, V. (2020). Individually Tailored Internet-Based Cognitive-Behavioral Therapy for Daily Functioning in Patients with Parkinson’s Disease: A Randomized Controlled Trial. In Journal of Parkinson’s Disease (Vol. 10, Issue 2, pp. 653–664). https://doi.org/10.3233/jpd-191894
22. Månsson, K. N. T., Cortes, D. S., Manzouri, A., Li, T.-Q., Hau, S., & Fischer, H. (2020). Viewing Pictures Triggers Rapid Morphological Enlargement in the Human Visual Cortex. Cerebral Cortex , 30(3), 851–857. https://doi.org/10.1093/cercor/bhz131
21. Han, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Månsson, K. N. T., Lindqvist, D., Boks, M. P., Révész, D., Mellon, S. H., & Picard, M. (2019). Accelerating research on biological aging and mental health: Current challenges and future directions. Psychoneuroendocrinology, 106, 293–311. https://doi.org/10.1016/j.psyneuen.2019.04.004
20. Hjorth, O. R., Frick, A., Gingnell, M., Hoppe, J. M., Faria, V., Hultberg, S., Alaie, I., Månsson, K. N. T., Wahlstedt, K., Jonasson, M., Lubberink, M., Antoni, G., Fredrikson, M., & Furmark, T. (2019). Expression and co-expression of serotonin and dopamine transporters in social anxiety disorder: a multitracer positron emission tomography study. Molecular Psychiatry. https://doi.org/10.1038/s41380-019-0618-7
19. Månsson, K. N. T., Lindqvist, D., Yang, L. L., Svanborg, C., Isung, J., Nilsonne, G., Bergman-Nordgren, L., El Alaoui, S., Hedman-Lagerlöf, E., Kraepelien, M., Högström, J., Andersson, G., Boraxbekk, C.-J., Fischer, H., Lavebratt, C., Wolkowitz, O. M., & Furmark, T. (2019). Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. Translational Psychiatry, 9(1), 340. https://doi.org/10.1038/s41398-019-0668-2
18. Rozental, A., Kottorp, A., Forsström, D., Månsson, K. N. T., Boettcher, J., Andersson, G., Furmark, T., & Carlbring, P. (2019). The Negative Effects Questionnaire: psychometric properties of an instrument for assessing negative effects in psychological treatments. Behavioural and Cognitive Psychotherapy, 47(5), 559–572. https://doi.org/10.1017/S1352465819000018
17. Frick, A., & Månsson, K. N. T. (2018). Brain changes in social anxiety disorder run in the family [Review of Brain changes in social anxiety disorder run in the family]. EBioMedicine, 36, 5–6. https://doi.org/10.1016/j.ebiom.2018.09.009
16. Goodwin, G. M., Holmes, E. A., Andersson, E., Browning, M., Jones, A., Lass-Hennemann, J., Månsson, K. N. T., Moessnang, C., Salemink, E., Sanchez, A., van Zutphen, L., & Visser, R. M. (2018). From neuroscience to evidence based psychological treatments - The promise and the challenge, ECNP March 2016, Nice, France. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 28(2), 317–333. https://doi.org/10.1016/j.euroneuro.2017.10.036
15. Ivanov, V. Z., Enander, J., Mataix-Cols, D., Serlachius, E., Månsson, K. N. T., Andersson, G., Flygare, O., Tolin, D., & Rück, C. (2018). Enhancing group cognitive-behavioral therapy for hoarding disorder with between-session Internet-based clinician support: A feasibility study. Journal of Clinical Psychology, 74(7), 1092–1105. https://doi.org/10.1002/jclp.22589
14. Lenhard, F., Sauer, S., Andersson, E., Månsson, K. N. T., Mataix-Cols, D., Rück, C., & Serlachius, E. (2018). Prediction of outcome in internet-delivered cognitive behaviour therapy for paediatric obsessive-compulsive disorder: A machine learning approach. International Journal of Methods in Psychiatric Research, 27(1). https://doi.org/10.1002/mpr.1576
13. Bas-Hoogendam, J. M., van Steenbergen, H., Nienke Pannekoek, J., Fouche, J.-P., Lochner, C., Hattingh, C. J., Cremers, H. R., Furmark, T., Månsson, K. N. T., Frick, A., Engman, J., Boraxbekk, C.-J., Carlbring, P., Andersson, G., Fredrikson, M., Straube, T., Peterburs, J., Klumpp, H., Phan, K. L., … van der Wee, N. J. A. (2017). Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder. NeuroImage. Clinical, 16, 678–688. https://doi.org/10.1016/j.nicl.2017.08.001
12. Faria, V., Gingnell, M., Hoppe, J. M., Hjorth, O., Alaie, I., Frick, A., Hultberg, S., Wahlstedt, K., Engman, J., Månsson, K. N. T., Carlbring, P., Andersson, G., Reis, M., Larsson, E.-M., Fredrikson, M., & Furmark, T. (2017). Do You Believe It? Verbal Suggestions Influence the Clinical and Neural Effects of Escitalopram in Social Anxiety Disorder: A Randomized Trial. EBioMedicine, 24, 179–188. https://doi.org/10.1016/j.ebiom.2017.09.031
11. Månsson, K. N. T., Salami, A., Carlbring, P., Boraxbekk, C.-J., Andersson, G., & Furmark, T. (2017). Structural but not functional neuroplasticity one year after effective cognitive behaviour therapy for social anxiety disorder. Behavioural Brain Research, 318, 45–51. https://doi.org/10.1016/j.bbr.2016.11.018
10. Månsson, K. N. T., Klintmalm, H., Nordqvist, R., & Andersson, G. (2017). Conventional Cognitive Behavioral Therapy Facilitated by an Internet-Based Support System: Feasibility Study at a Psychiatric Outpatient Clinic. JMIR Research Protocols, 6(8), e158. https://doi.org/10.2196/resprot.6035
9. Brännström, K. J., Öberg, M., Ingo, E., Månsson, K. N. T., Andersson, G., Lunner, T., & Laplante-Lévesque, A. (2016). The initial evaluation of an Internet-based support system for audiologists and first-time hearing aid clients. Internet Interventions, 4, 82–91. https://doi.org/10.1016/j.invent.2016.01.002
8. Månsson, K. N. T., Salami, A., Frick, A., Carlbring, P., Andersson, G., Furmark, T., & Boraxbekk, C.-J. (2016). Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder. Translational Psychiatry, 6, e727. https://doi.org/10.1038/tp.2015.218
7. Brännström, K. J., Öberg, M., Ingo, E., Månsson, K. N. T., Andersson, G., Lunner, T., & Laplante-Lévesque, A. (2015). The Process of Developing an Internet-Based Support System for Audiologists and First-Time Hearing Aid Clients. American Journal of Audiology, 24(3), 320–324. https://doi.org/10.1044/2015_AJA-14-0094
6. Månsson, K. N. T., Frick, A., Boraxbekk, C.-J., Marquand, A. F., Williams, S. C. R., Carlbring, P., Andersson, G., & Furmark, T. (2015). Predicting long-term outcome of Internet-delivered cognitive behavior therapy for social anxiety disorder using fMRI and support vector machine learning. Translational Psychiatry, 5, e530. https://doi.org/10.1038/tp.2015.22
5. Nilsonne, G., Tamm, S., Månsson, K. N. T., Åkerstedt, T., & Lekander, M. (2015). Leukocyte telomere length and hippocampus volume: a meta-analysis. F1000Research, 4, 1073. https://doi.org/10.12688/f1000research.7198.1
4. Tulbure, B. T., Szentagotai, A., David, O., Ștefan, S., Månsson, K. N. T., David, D., & Andersson, G. (2015). Internet-delivered cognitive-behavioral therapy for social anxiety disorder in Romania: a randomized controlled trial. PloS One, 10(5), e0123997. https://doi.org/10.1371/journal.pone.0123997
3. Månsson, K. N. T., Carlbring, P., Frick, A., Engman, J., Olsson, C.-J., Bodlund, O., Furmark, T., & Andersson, G. (2013). Altered neural correlates of affective processing after internet-delivered cognitive behavior therapy for social anxiety disorder. Psychiatry Research, 214(3), 229–237. https://doi.org/10.1016/j.pscychresns.2013.08.012
2. Månsson, K. N. T.,Skagius Ruiz, E., Gervind, E., Dahlin, M., & Andersson, G. (2013). Development and initial evaluation of an Internet-based support system for face-to-face cognitive behavior therapy: a proof of concept study. Journal of Medical Internet Research, 15(12), e280. https://doi.org/10.2196/jmir.3031
1. Tulbure, B. T., Månsson, K. N. T., & Andersson, G. (2012). Internet treatment for social anxiety disorder in Romania: study protocol for a randomized controlled trial. Trials, 13, 202. https://doi.org/10.1186/1745-6215-13-202
Funding sources
We are grateful for the generous support provided by
Center for Innovative Medicine (CIMED)
StratNeuro
Karolinska Institutet
Swedish Research Council (Vetenskapsrådet)
Swedish Brain Foundation
Media presence
Our research in the media:
Scientific American
"Cognitive-behavioral therapy improved both symptoms and markers of senescence in people with anxiety" Click here to go to the Scientific American magazine
Forskning & Framsteg
Rätt hjärnmönster för en lyckad terapi. En undersökning av hjärnans aktivitet avslöjar hur patienten kommer att svara på behandling med KBT. Klicka här för att läsa artikeln
Psykologtidningen
Biologi och psykologi i förening kan bidra till effektivare och mer individanpassad psykologisk behandling. Ladda hem artikeln här
Contact details
Kristoffer Månsson
kristoffer.mansson@
mansson@
Phone
+46 (0) 70 580 3267
Copyright 2022