• Things we like to do

    Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome

    Månsson, K. N. T., Waschke, L., Manzouri, A., Furmark, T., Fischer, H., & Garrett, D. D. (2021). Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2021.09.026
     
    Presentation on YouTube, click here!

    Cellular protection and biological aging in social anxiety disordered patients receiving cognitive-behavioral therapy (CBT)

    Månsson, K. N. T., et al. (2019). Translational Psychiatry, 9, 340. doi.org/10.1038/s41398-019-0668-2

    Image obtained from Daniel Lindqvist et al., Neurosci Biobehav Rev doi.org/10.1016/J.NEUBIOREV.2015.05.007​

    Investigate rapid brain plasticity using structural magnetic resonance imaging

    Månsson, K. N. T., et al. (2019). Cerebral Cortex: doi.org/10.1093/cercor/bhz131

    This study was featured as a cover image in Cerebral Cortex, march 2020. Illustration by Staffan Lager.
  • Latest news from the lab

    New paper out in Biological Psychiatry

    2021.10.11 New paper out in Biological Psychiatry: Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. The article is available for free, click here!

     

    A short YouTube on the paper, here!

    Assistant Professor in medical science

    2021.02.18 Exciting times ahead! Dr Månsson is awarded a position as Assistant Professor in medical science at Karolinska Institutet (starting 2022). The position includes research funding for 6 years, click here for more information.

    Awarded the best talk at the Alpine Brain Imaging Meeting

    2020.01.16 I got an award fot the best talk at the Alpine Brain Imaging Meeting in Champéry, Switzerland. See you next year! More info, click here!

  • We are hiring

    Contact us if you are interested

    Two open positions: PhD student

    Cerebellum and Emotional Networks (CEN) is a Marie Skłodowska-Curie Innovative Training Network that will explore the brain circuits that underlie emotional behaviour. We are about to announce two positions for PhD students (in collaboration with Professor Tomas Furmark at Uppsala University). TBA soon.

    Postdocs

    Reach out if you are interested in postdoctoral training.

    Internships

    We can host internships for international students visiting the lab for a few months. Contact us for more information.

  • Lab members

    Kristoffer N T Månsson, PhD

    Principal investigator

    Starting 2022: Assistant Professor in medical science, Karolinska Institutet
     
    Postdoctoral fellowships (2019-2022)
    • Dartmouth College, Hanover, New Hampshire, USA (PI: Tor Wager)
    • Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany (PI: Douglas D Garrett)
    Teaching
    • Study Director, Psychiatry Research School, Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (2017-2020)

    Amir Manzouri, MSc

    Research engineer, Department of Psychology, Stockholm University; Centre for Psychiatry Research, Karolinska Institutet

    Amir studied medical imaging at the Royal Institute of Technology in Stockholm and have been working with neuroimaging methods as a research engineer since 2010. Amir have been involved in research on Alzheimer’s disease, gender identity, emotion, stress and anxiety disorders. Amir have extensive experience with data collection (e.g., magnetic resonance imaging, MRI scanning), and expertise in data pre- and post-processing, higher level statistical analyses on functional MRI data, e.g., psycho-physiological interactions (PPI), partial least squares (PLS), support vector machines (SVM), and independent component analysis (ICA). Moreover, Amir also have extensive expertise in structural MRI data analysis, e.g., FreeSurfer, AFNI, BrainVoyager, and voxel based morphometry (VBM), and tract-based spatial statistics (TBSS).

    Mathilda Björkman, MSc

    Research Assistant/Intern Clinical Psychologist

    Mathilda is a research assistant in the lab and is involved in fMRI scanning och scheduling participants to an ongoing data collection. Mathilda is also an intern clinical psychologist under supervision (i.e., PTP) in adult general psychiatry. Mathilda is involved in a project investigating socio-affective neural response to predict the outcome of internet-based CBT in adults with common psychiatric disorders. Mathilda’s master thesis is entitled “Predicting psychiatric patients’ symptom improvement after internet-delivered cognitive behavioral therapy”.

    Alumni

    Theses (Bachelor or Master level theses)

    • Adam Yngve, Anna Stavenberg, Arian Jafari, Björn von Gegerfelt, Bo Jenner, Jennie Åberg Syed, Markus Söderqvist, Mathilda Björkman, Nils Isacsson, Simon Höglund, Örn Kolbeinsson
    • Laura Terlau (Osnabrück University, Germany), Virginia Berlose (University of Padoa, Italy)
  • Extended network and collaborations

    A selection of ongoing collaborations with principal investigators

    National collaborations

    • Andreas Frick, Uppsala University
    • Catharina Lavebratt, Karolinska Institutet
    • Daniel Lindqvist, Lunds University
    • Gerhard Andersson, Linköping University
    • Håkan Fischer, Stockholm University
    • Martin Lövdén, Gothenburg University
    • Mats Lekander, Stockholm University
    • Tie-Qiang Li, Karolinska Institutet
    • Tomas Furmark, Uppsala University
    • Tomas Ekström, Karolinska Institutet
    • Viktor Kaldo, Karolinska Institutet

    International collaborations

    • Douglas D Garrett, Max Planck Institute for Human Development, Berlin, Germany 
    • Tor D Wager, Dartmouth College, NH, United States 
    • Owen Wolkowitz, University of California, San Francisco, CA, United States
  • Brief presentations

    of selected publications

    Biomarkers in psychiatry remain elusive, and typical BOLD fMRI measures show low reliability. In...
    Read more...
  • Scientific publications

    Highlighted

    • Månsson, K. N. T., Waschke, L., Manzouri, A., Furmark, T., Fischer, H., & Garrett, D. D. (2021). Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2021.09.026
       
    • Månsson, K. N. T., Lasselin, J., Karshikoff, B., Axelsson, J., Engler, H., Schedlowski, M., Benson, S., Petrovic, P., & Lekander, M. (2021). Anterior insula morphology and vulnerability to psychopathology-related symptoms in response to acute inflammation. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2021.09.007
    • Månsson, K. N. T., Cortes, D. S., Manzouri, A., Hau, S., Fischer, H. (2019) Viewing pictures triggers rapid morphological enlargement in the human visual cortex. Cerebral Cortex: https://doi.org/10.1093/cercor/bhz131
       
    • Månsson, K. N. T., Lindqvist, D., Yang, L., Svanborg, C., Isung, J., Nilsonne, G., Bergman Nordgren, L., El Alaoui, S., Hedman-Lagerlöf, E., Kraepelien, M., Högström, J., Andersson, G., Boraxbekk, CJ., Fischer, H., Lavebratt, C., Wolkowitz, O., Furmark, T. (2019) Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. Translational Psychiatry, 9, 340. https://doi.org/10.1038/s41398-019-0668-2

    Peer-reviewed

    • 32. Månsson, K. N. T., Waschke, L., Manzouri, A., Furmark, T., Fischer, H., & Garrett, D. D. (2021). Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2021.09.026

    • 31. Månsson, K. N. T., Lasselin, J., Karshikoff, B., Axelsson, J., Engler, H., Schedlowski, M., Benson, S., Petrovic, P., & Lekander, M. (2021). Anterior insula morphology and vulnerability to psychopathology-related symptoms in response to acute inflammation. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2021.09.007

    • 30. Hjorth, O., Frick, A., Gingnell, M., Motilla-Hoppe, J., Faria, V., Hultberg, S., Alaie, I., Månsson, K.N.T., Rosén, J., Reis, M., Wahlstedt, K., Jonasson, M., Lubberink, M., Antoni, G., Fredriksson, M., Furmark, T. Expectancy effects on serotonin and dopamine transporters during SSRI treatment of social anxiety disorder: A randomized clinical trial. Transl. Psychiatry. In press

    • 29. Koenig, J., Abler, B., Agartz, I., Åkerstedt, T., Andreassen, O. A., Anthony, M., Bär, K.-J., Bertsch, K., Brown, R. C., Brunner, R., Carnevali, L., Critchley, H. D., Cullen, K. R., de Geus, E. J. C., de la Cruz, F., Dziobek, I., Ferger, M. D., Fischer, H., Flor, H., … Månsson, K. N. T., … Quintana, D. S. (2021). Cortical thickness and resting-state cardiac function across the lifespan: A cross-sectional pooled mega-analysis. Psychophysiology, 58(7), e13688. https://doi.org/10.1111/psyp.13688

    • 28. Li, X., Fischer, H., Manzouri, A., Månsson, K. N. T., & Li, T.-Q. (2021). Dataset of whole-brain resting-state fMRI of 227 young and elderly adults acquired at 3T. Data in Brief, 38, 107333. https://doi.org/10.1016/j.dib.2021.107333

    • 27. Månsson, K. N. T., Lueken, U., & Frick, A. (2021). Enriching CBT by Neuroscience: Novel Avenues to Achieve Personalized Treatments. International Journal of Cognitive Therapy, 14(1), 182–195. https://doi.org/10.1007/s41811-020-00089-0

    • 26. Åkerstedt, T., Lekander, M., Nilsonne, G., Tamm, S., d’Onofrio, P., Kecklund, G., Fischer, H., Schwarz, J., Petrovic, P., & Månsson, K. N. T. (2020). Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults. Nature and Science of Sleep, 12, 289–298. https://doi.org/10.2147/NSS.S240493

    • 25. Bas-Hoogendam, J. M., Groenewold, N. A., Aghajani, M., Freitag, G. F., Harrewijn, A., Hilbert, K., Jahanshad, N., Thomopoulos, S. I., Thompson, P. M., Veltman, D. J., Winkler, A. M., Lueken, U., Pine, D. S., van der Wee, N. J. A., Stein, D. J., & ENIGMA-Anxiety Working Group. (2020). ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders. Human Brain Mapping, hbm.25100. https://doi.org/10.1002/hbm.25100

    • 24. Costache, M. E., Frick, A., Månsson, K. N. T., Engman, J., Faria, V., Hjorth, O., Hoppe, J. M., Gingnell, M., Frans, Ö., Björkstrand, J., Rosén, J., Alaie, I., Åhs, F., Linnman, C., Wahlstedt, K., Tillfors, M., Marteinsdottir, I., Fredrikson, M., & Furmark, T. (2020). Higher- and lower-order personality traits and cluster subtypes in social anxiety disorder. PloS One, 15(4), e0232187. https://doi.org/10.1371/journal.pone.0232187

    • 23. Kraepelien, M., Schibbye, R., Månsson, K. N. T., Sundström, C., Riggare, S., Andersson, G., Lindefors, N., Svenningsson, P., & Kaldo, V. (2020). Individually Tailored Internet-Based Cognitive-Behavioral Therapy for Daily Functioning in Patients with Parkinson’s Disease: A Randomized Controlled Trial. In Journal of Parkinson’s Disease (Vol. 10, Issue 2, pp. 653–664). https://doi.org/10.3233/jpd-191894

    • 22. Månsson, K. N. T., Cortes, D. S., Manzouri, A., Li, T.-Q., Hau, S., & Fischer, H. (2020). Viewing Pictures Triggers Rapid Morphological Enlargement in the Human Visual Cortex. Cerebral Cortex , 30(3), 851–857. https://doi.org/10.1093/cercor/bhz131

    • 21. Han, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Månsson, K. N. T., Lindqvist, D., Boks, M. P., Révész, D., Mellon, S. H., & Picard, M. (2019). Accelerating research on biological aging and mental health: Current challenges and future directions. Psychoneuroendocrinology, 106, 293–311. https://doi.org/10.1016/j.psyneuen.2019.04.004

    • 20. Hjorth, O. R., Frick, A., Gingnell, M., Hoppe, J. M., Faria, V., Hultberg, S., Alaie, I., Månsson, K. N. T., Wahlstedt, K., Jonasson, M., Lubberink, M., Antoni, G., Fredrikson, M., & Furmark, T. (2019). Expression and co-expression of serotonin and dopamine transporters in social anxiety disorder: a multitracer positron emission tomography study. Molecular Psychiatry. https://doi.org/10.1038/s41380-019-0618-7

    • 19. Månsson, K. N. T., Lindqvist, D., Yang, L. L., Svanborg, C., Isung, J., Nilsonne, G., Bergman-Nordgren, L., El Alaoui, S., Hedman-Lagerlöf, E., Kraepelien, M., Högström, J., Andersson, G., Boraxbekk, C.-J., Fischer, H., Lavebratt, C., Wolkowitz, O. M., & Furmark, T. (2019). Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. Translational Psychiatry, 9(1), 340. https://doi.org/10.1038/s41398-019-0668-2

    • 18. Rozental, A., Kottorp, A., Forsström, D., Månsson, K. N. T., Boettcher, J., Andersson, G., Furmark, T., & Carlbring, P. (2019). The Negative Effects Questionnaire: psychometric properties of an instrument for assessing negative effects in psychological treatments. Behavioural and Cognitive Psychotherapy, 47(5), 559–572. https://doi.org/10.1017/S1352465819000018

    • 17. Frick, A., & Månsson, K. N. T. (2018). Brain changes in social anxiety disorder run in the family [Review of Brain changes in social anxiety disorder run in the family]. EBioMedicine, 36, 5–6. https://doi.org/10.1016/j.ebiom.2018.09.009

    • 16. Goodwin, G. M., Holmes, E. A., Andersson, E., Browning, M., Jones, A., Lass-Hennemann, J., Månsson, K. N. T., Moessnang, C., Salemink, E., Sanchez, A., van Zutphen, L., & Visser, R. M. (2018). From neuroscience to evidence based psychological treatments - The promise and the challenge, ECNP March 2016, Nice, France. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 28(2), 317–333. https://doi.org/10.1016/j.euroneuro.2017.10.036

    • 15. Ivanov, V. Z., Enander, J., Mataix-Cols, D., Serlachius, E., Månsson, K. N. T., Andersson, G., Flygare, O., Tolin, D., & Rück, C. (2018). Enhancing group cognitive-behavioral therapy for hoarding disorder with between-session Internet-based clinician support: A feasibility study. Journal of Clinical Psychology, 74(7), 1092–1105. https://doi.org/10.1002/jclp.22589

    • 14. Lenhard, F., Sauer, S., Andersson, E., Månsson, K. N. T., Mataix-Cols, D., Rück, C., & Serlachius, E. (2018). Prediction of outcome in internet-delivered cognitive behaviour therapy for paediatric obsessive-compulsive disorder: A machine learning approach. International Journal of Methods in Psychiatric Research, 27(1). https://doi.org/10.1002/mpr.1576

    • 13. Bas-Hoogendam, J. M., van Steenbergen, H., Nienke Pannekoek, J., Fouche, J.-P., Lochner, C., Hattingh, C. J., Cremers, H. R., Furmark, T., Månsson, K. N. T., Frick, A., Engman, J., Boraxbekk, C.-J., Carlbring, P., Andersson, G., Fredrikson, M., Straube, T., Peterburs, J., Klumpp, H., Phan, K. L., … van der Wee, N. J. A. (2017). Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder. NeuroImage. Clinical, 16, 678–688. https://doi.org/10.1016/j.nicl.2017.08.001

    • 12. Faria, V., Gingnell, M., Hoppe, J. M., Hjorth, O., Alaie, I., Frick, A., Hultberg, S., Wahlstedt, K., Engman, J., Månsson, K. N. T., Carlbring, P., Andersson, G., Reis, M., Larsson, E.-M., Fredrikson, M., & Furmark, T. (2017). Do You Believe It? Verbal Suggestions Influence the Clinical and Neural Effects of Escitalopram in Social Anxiety Disorder: A Randomized Trial. EBioMedicine, 24, 179–188. https://doi.org/10.1016/j.ebiom.2017.09.031

    • 11. Månsson, K. N. T., Salami, A., Carlbring, P., Boraxbekk, C.-J., Andersson, G., & Furmark, T. (2017). Structural but not functional neuroplasticity one year after effective cognitive behaviour therapy for social anxiety disorder. Behavioural Brain Research, 318, 45–51. https://doi.org/10.1016/j.bbr.2016.11.018

    • 10. Månsson, K. N. T., Klintmalm, H., Nordqvist, R., & Andersson, G. (2017). Conventional Cognitive Behavioral Therapy Facilitated by an Internet-Based Support System: Feasibility Study at a Psychiatric Outpatient Clinic. JMIR Research Protocols, 6(8), e158. https://doi.org/10.2196/resprot.6035

    • 9. Brännström, K. J., Öberg, M., Ingo, E., Månsson, K. N. T., Andersson, G., Lunner, T., & Laplante-Lévesque, A. (2016). The initial evaluation of an Internet-based support system for audiologists and first-time hearing aid clients. Internet Interventions, 4, 82–91. https://doi.org/10.1016/j.invent.2016.01.002

    • 8. Månsson, K. N. T., Salami, A., Frick, A., Carlbring, P., Andersson, G., Furmark, T., & Boraxbekk, C.-J. (2016). Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder. Translational Psychiatry, 6, e727. https://doi.org/10.1038/tp.2015.218

    • 7. Brännström, K. J., Öberg, M., Ingo, E., Månsson, K. N. T., Andersson, G., Lunner, T., & Laplante-Lévesque, A. (2015). The Process of Developing an Internet-Based Support System for Audiologists and First-Time Hearing Aid Clients. American Journal of Audiology, 24(3), 320–324. https://doi.org/10.1044/2015_AJA-14-0094

    • 6. Månsson, K. N. T., Frick, A., Boraxbekk, C.-J., Marquand, A. F., Williams, S. C. R., Carlbring, P., Andersson, G., & Furmark, T. (2015). Predicting long-term outcome of Internet-delivered cognitive behavior therapy for social anxiety disorder using fMRI and support vector machine learning. Translational Psychiatry, 5, e530. https://doi.org/10.1038/tp.2015.22

    • 5. Nilsonne, G., Tamm, S., Månsson, K. N. T., Åkerstedt, T., & Lekander, M. (2015). Leukocyte telomere length and hippocampus volume: a meta-analysis. F1000Research, 4, 1073. https://doi.org/10.12688/f1000research.7198.1

    • 4. Tulbure, B. T., Szentagotai, A., David, O., Ștefan, S., Månsson, K. N. T., David, D., & Andersson, G. (2015). Internet-delivered cognitive-behavioral therapy for social anxiety disorder in Romania: a randomized controlled trial. PloS One, 10(5), e0123997. https://doi.org/10.1371/journal.pone.0123997

    • 3. Månsson, K. N. T., Carlbring, P., Frick, A., Engman, J., Olsson, C.-J., Bodlund, O., Furmark, T., & Andersson, G. (2013). Altered neural correlates of affective processing after internet-delivered cognitive behavior therapy for social anxiety disorder. Psychiatry Research, 214(3), 229–237. https://doi.org/10.1016/j.pscychresns.2013.08.012

    • 2. Månsson, K. N. T.,Skagius Ruiz, E., Gervind, E., Dahlin, M., & Andersson, G. (2013). Development and initial evaluation of an Internet-based support system for face-to-face cognitive behavior therapy: a proof of concept study. Journal of Medical Internet Research, 15(12), e280. https://doi.org/10.2196/jmir.3031

    • 1. Tulbure, B. T., Månsson, K. N. T., & Andersson, G. (2012). Internet treatment for social anxiety disorder in Romania: study protocol for a randomized controlled trial. Trials, 13, 202. https://doi.org/10.1186/1745-6215-13-202

  • Funding sources

    We are grateful for the generous support provided by

    Karolinska Institutet

    Funding for position as Assistant Professor in medical science at Karolinska Institutet.

    Swedish Research Council (Vetenskapsrådet)

    International post doc, 3 year funding: "Improving psychological treatments for anxiety disorders by investigating the temporal dynamics of brain’s neural responses"

    Swedish Brain Foundation

    Funding provided 2016, 2018, and 2019, in research projects in collaboration with Professor Tomas Furmark (main applicant).
     
  • Media presence

    Our research in the media:

    Scientific American

    "Cognitive-behavioral therapy improved both symptoms and markers of senescence in people with anxiety" Click here to go to the Scientific American magazine

    Forskning & Framsteg

    Rätt hjärnmönster för en lyckad terapi. En undersökning av hjärnans aktivitet avslöjar hur patienten kommer att svara på behandling med KBT. Klicka här för att läsa artikeln

    Psykologtidningen

    Biologi och psykologi i förening kan bidra till effektivare och mer individanpassad psykologisk behandling. Ladda hem artikeln här

  • Twitter

    @neuronsson

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