• Things we like to do

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    Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome

    Månsson, K. N. T., Waschke, L., Manzouri, A., Furmark, T., Fischer, H., & Garrett, D. D. (2022). Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2021.09.026

     

    Presentation on YouTube, click here!

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    Honorable Mention from Biological Psychiatry's Somerfeld-Ziskind Research Award

    We are very honored to be short-listed for the 2023 Somerfeld-Ziskind Research Award. Thanks!

     

    Månsson, K. N. T., Waschke, L., Manzouri, A., Furmark, T., Fischer, H., & Garrett, D. D. (2022). Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2021.09.026

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    Investigate rapid brain plasticity using structural magnetic resonance imaging

    Olivo, G., Lövdén, M., Manzouri, A., Terlau, L., Jenner, B., Jafari, A., Petersson, S., Li, T.-Q., Fischer, H., & Månsson, K. N. T. (2022). Estimated Gray Matter Volume Rapidly Changes after a Short Motor Task. Cerebral Cortex. https://doi.org/10.1093/cercor/bhab488

     

    Månsson, K. N. T., Cortes, D. S., Manzouri, A., Li, T.-Q., Hau, S., & Fischer, H. (2020). Viewing Pictures Triggers Rapid Morphological Enlargement in the Human Visual Cortex. Cerebral Cortex , 30(3), 851–857. https://doi.org/10.1093/cercor/bhz131


    The illustration was featured as a cover image in Cerebral Cortex, march 2020. Illustration by Staffan Lager.

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    Cellular protection and biological aging in social anxiety disordered patients receiving cognitive-behavioral therapy (CBT)

    Månsson, K. N. T., et al. (2019). Translational Psychiatry, 9, 340. doi.org/10.1038/s41398-019-0668-2


    Image obtained from Daniel Lindqvist et al., Neurosci Biobehav Rev doi.org/10.1016/J.NEUBIOREV.2015.05.007​

  • Latest news from the lab

    Funding from the Swedish Research Council

    2023.11.06: New grant. The Swedish Research Council awarded Dr Månsson and collaborators (Professor Tor Wager, Mats Lekander and Dr Joar Gusterstam) with 6 MSEK for a project entitled "Placebo responsiveness and cognitive behavior therapy outcomes: Investigating expectations and neural variability in anxious individuals". Exciting project coming up!

    Large European grant to investigate children and adolescents in Romania

    2023.08.21: New grant with Babeș-Bolyai University, Romania. More exciting times ahead! Dr Månsson received €1.300.000 from the European Union and the Romanian Government to investigate anxiety and depression in children and adolecents. More information to come!

    Funding to study humans and zebrafish

    2022.10.14: New grant. Dr Månsson and Dr Ampatzis received funding from KIRI Fellow "Investigations of brain signal variability and rapid plasticity during approach-avoidance of fear: experiments of humans and zebrafish". Postdoc position will soon be announced!

    New grant from the Swedish Brain Foundation (Hjärnfonden)

    2022.07.04: New grant. Dr Månsson received 600.000 SEK from the Swedish Brain Foundation for a project entitled "Placebo response in cognitive behavior therapy: An experimental study on expectations in social anxiety disorder". Thanks to Hjärnfonden!

    2.4 MSEK to investigate psychiatric patients' neural variability

    2022.06.27: New grant. Dr Månsson was awarded 2.400.000 SEK for a study aiming at "Predicting cognitive behavior therapy outcome with patients’ expectations and neural variability". We look forward to continue our collaborative efforts with Region Stockholm health care and Internetpsykiatri at campus Flemingsbergs. Thanks to CIMED and Region Stockholm!

    Prize at StratNeuro Retreat

    2022.05.20 At the StratNeuro Retreat 2022 (more info here), Dr Månsson was awarded the best clinical/translational poster.

    KIRI Fellow

    2022.04.22: KIRI Fellow. Dr Månsson is a KIRI Fellow 2022. Karolinska Institutet's Research Incubator (KIRI) is a research forum in which a new generation of researchers can collaborate and develop joint interdisciplinary research projects in a unique interdisciplinary environment. Click here to read more!

    Assistant Professor in medical science

    2021.02.18: New grant and academic position. Exciting times ahead! Dr Månsson is awarded a position as Assistant Professor in medical science at Karolinska Institutet (starting 2022). The position includes research funding for 6 years, click here for more information.

  • Team

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    Kristoffer N T Månsson, PhD

    Principal investigator, Associate Professor at Karolinska Institutet

    Previous academic positions

    • Visiting faculty, Dartmouth College, Hanover, New Hampshire, USA (PI: Tor Wager)
    • Post doc, Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany (PI: Douglas D Garrett)
    • Post doc, Department of Psychology, Stockholm University, Sweden (PI: Håkan Fischer)
    • Study Director, Psychiatry Research School, Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (2017-2020)
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    Konstantinos Tsikonofilos, PhD

    Postdoc

    Dr Tsikonofilos holds a Diploma in Applied Mathematical and Physical Sciences from the National Technical University of Athens, an MSc in Biomedical Engineering, and a PhD in Bioengineering from Imperial College London, UK. With expertise in statistics, computer science, and neurotechnology, he specializes in analyzing various datasets including spiking, local field potential, ECoG, EEG, and fMRI. His skills encompass signal processing, machine learning and statistical modeling, graph theory and computational modeling, with experience in experimental design and data collection of electrophysiological signals, as well as preclinical modeling of brain injury.

     

    Dr Tsikonofilos previous research had a clinical focus on cognitive enhancers, hearing loss, cochlear implant design, and traumatic brain injury. Currently a postdoctoral researcher in the lab, he will work towards uncovering biomarkers of psychiatric disorders and treatment outcomes and exploring the role of neural variability and plasticity in fear avoidance behavior, utilizing multimodal datasets.

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    Amir Manzouri, MSc

    Research engineer

    Amir studied medical imaging at the Royal Institute of Technology in Stockholm and has been working with neuroimaging methods as a research engineer since 2010. Amir has been involved in research on Alzheimer’s disease, gender identity, emotion, stress and anxiety disorders. Amir has extensive experience with data collection (e.g., magnetic resonance imaging, MRI scanning), and expertise in data pre- and post-processing, higher level statistical analyses on functional MRI data, e.g., psycho-physiological interactions (PPI), partial least squares (PLS), support vector machines (SVM), and independent component analysis (ICA). Moreover, Amir also has extensive expertise in structural MRI data analysis, e.g., FreeSurfer, AFNI, BrainVoyager, and voxel based morphometry (VBM), and tract-based spatial statistics (TBSS).

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    Alice Doubliez

    Visiting PhD student (University Hospital Essen)

    Alice is a PhD student in Prof. Timmann's Experimental Neurology laboratory at Essen University Hospital, Germany, and is staying with us as part of the Cerebellar & Emotional Networks Consortium collaboration. Alice project focuses on the contribution of the human cerebellum on fear extinction learning. Specifically, she investigates the cerebellum's involvement in processing reward prediction error by pharmacologically modulating the dopaminergic system prior fear extinction. During her stay, she will develop her skills in fMRI manual denoising, preprocessing and data analysis.

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    Enzo Nio

    Visiting PhD student (University Hospital Essen)

    Enzo is a PhD student working at the University Hospital Essen in Germany, and a visitor to the lab as part of the Cerebellar & Emotional Networks consortium. He is researching the role of the cerebellum in fear extinction, and how this brain structure might interact with the reward system to contribute to reward prediction error processing, thought to drive fear extinction. In his stay in the lab, he will learn about manual fMRI denoising techniques and how to apply these on a collected 7T fMRI 3-day fear conditioning paradigm dataset.

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    Jingjing Ye

    Visiting PhD student (University of Edinburgh)

    Jingjing Ye is a PhD student from University of Edinburgh. Jing's project focuses on using functional MRI to understand cerebellar and emotional network in rat model of autism.

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    Oana Munteanu, MD

    PhD student

    Oana is a PhD student, and a medical child and adolescent psychiatry resident at Babeș-Bolyai University in Cluj-Napoca, Romania. Oana participates in the development of a study to investigates the neural correlates of social fear learning among adolescents diagnosed with anxiety disorders.

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    Tuğçe Yıldız, MSc

    PhD student

    Tuğçe completed a BSc in psychology in Turkey, and MSc in Cognitive Neuroscience and Clinical Neuropsychology at Padova University, Italy, before joining the lab as a PhD student. Tuğçe will use a variety of scientific methods and analytic techniques to investigate the brain of patients with social anxiety disorder, including functional and structural magnetic resonance imaging (MRI), and magnetoencephalography (MEG). For instance, Tuğçe will investigate brain signal variability and signal complexity, as well as gray matter volume in patients with social anxiety disorder.

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    Elise Björnelius

    Research Assistant

    Elise is a student at Psykologprogrammet (Master of Psychology), Stockholm University and a research assistant in the lab. Specifically, Elise is supporting the TreVar research project by coordinating information and participants recruited from a psychiatric clinic within Region Stockholm. Elise interview and schedule participants, assist other staff at the magnetic resonance imaging (MRI) scanner, as well as setting up a computerized experiment for our participants.

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    Hjalmar Lindström

    Research Assistant

    Hjalmar is currently studying his third year at the Natural Science Program, Viktor Rydberg Gymnasium, Odenplan. Hjalmar is supporting the lab with fMRI signal denoising and behavioral data management.

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    Josefine Tigerstedt Andresen

    Research Assistant

    Josefine is currently studying her second year at läkarprogrammet (medical degree), Karolinska institutet. She works as a research assistant in the lab. Josefine is supporting the TreVar research project.

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    Marion Erlandsdotter

    Research Assistant

    Marion is a student at Psykologprogrammet (Master of Psychology), Stockholm University and a research assistant in the lab. Specifically, Marion is supporting the TreVar research project by coordinating information and participants recruited from a psychiatric clinic within Region Stockholm. Marion interview and schedule participants, assist other staff at the magnetic resonance imaging (MRI) scanner, as well as setting up a computerized experiment for our participants.

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    Sebastian Gustafsson

    Research Assistant

    Sebastian is a student at Psykologprogrammet (Master of Psychology), Karolinska Institutet and a research assistant in the lab. Sebastian is supporting the TreVar research project with healthy control recruitment.

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    Alumni

    Internships and Bachelor or Master level theses

    • National: Adam Yngve, Anna Stavenberg, Arian Jafari, Björn von Gegerfelt, Bo Jenner, Jennie Åberg Syed, Johannes Mogren, Markus Söderqvist, Mathilda Björkman, Nikolay Popov, Nils Isacsson, Sara Rajjala, Simon Höglund, Örn Kolbeinsson
    • International: Laura Terlau (Osnabrück University, Germany), Liisbeth Pirn (University of Munich, Germany), Virginia Berlose (University of Padoa, Italy), Alice Clerouin (Ecole Normale Supérieure, France), Katarzyna Karpa (Universität Heidelberg, Germany), Sara Halmans (University of Lübeck, Germany), Federica Mazzilli (Vita-Salute San Raffaele University, Milan, Italy)
  • Extended network and collaborations

    A selection of ongoing collaborations with principal investigators

    Collaborators

    • Andreas Frick, Uppsala University
    • Brjánn Ljótsson, Karolinska Institutet
    • Catharina Lavebratt, Karolinska Institutet
    • Daniel Lindqvist, Lunds University
    • Douglas D Garrett, Max Planck Institute for Human Development, Berlin, Germany
    • Gerhard Andersson, Linköping University
    • Håkan Fischer, Stockholm University
    • Fredrik Åhs, Mid Sweden University
    • Julie Lasselin, Karolinska Institutet

     

    • Martin Lövdén, Gothenburg University
    • Mats Lekander, Stockholm University
    • Tie-Qiang Li, Karolinska Institutet
    • Tomas Furmark, Uppsala University
    • Tomas Ekström, Karolinska Institutet
    • Tor D Wager, Dartmouth College, NH, United States
    • Torbjörn Åkerstedt, Stockholm University
    • Owen Wolkowitz, University of California, San Francisco, CA, United States
    • Viktor Kaldo, Karolinska Institutet
  • Brief presentations

    What are your participants doing while youacquire the anatomical MRI brain scans? Our latest show...
    Read more...
    Biomarkers in psychiatry remain elusive, and typical BOLD fMRI measures show low reliability. In...
    Read more...
  • Publications

    Highlighted

    • Lindqvist, D., Furmark, T., Lavebratt, C., Ohlsson, L., & Månsson, K. N. T. (2022). Plasma circulating cell-free mitochondrial DNA in social anxiety disorder. Psychoneuroendocrinology, 148, 106001. https://doi.org/10.1016/j.psyneuen.2022.106001
       
    • Månsson, K. N. T., Waschke, L., Manzouri, A., Furmark, T., Fischer, H., & Garrett, D. D. (2022). Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2021.09.026
       
    • Olivo, G., Lövdén, M., Manzouri, A., Terlau, L., Jenner, B., Jafari, A., Petersson, S., Li, T.-Q., Fischer, H., & Månsson, K. N. T. (2022). Estimated Gray Matter Volume Rapidly Changes after a Short Motor Task. Cerebral Cortex. https://doi.org/10.1093/cercor/bhab488
       
    • Månsson, K. N. T., Cortes, D. S., Manzouri, A., Hau, S., Fischer, H. (2019) Viewing pictures triggers rapid morphological enlargement in the human visual cortex. Cerebral Cortex: https://doi.org/10.1093/cercor/bhz131
       
    • Månsson, K. N. T., Lasselin, J., Karshikoff, B., Axelsson, J., Engler, H., Schedlowski, M., Benson, S., Petrovic, P., & Lekander, M. (2021). Anterior insula morphology and vulnerability to psychopathology-related symptoms in response to acute inflammation. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2021.09.007
    • Månsson, K. N. T., Lindqvist, D., Yang, L., Svanborg, C., Isung, J., Nilsonne, G., Bergman Nordgren, L., El Alaoui, S., Hedman-Lagerlöf, E., Kraepelien, M., Högström, J., Andersson, G., Boraxbekk, CJ., Fischer, H., Lavebratt, C., Wolkowitz, O., Furmark, T. (2019) Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. Translational Psychiatry, 9, 340. https://doi.org/10.1038/s41398-019-0668-2

    Peer-reviewed

    • 42. Laukka, P., Månsson, K. N. T., Cortes, D. S., Manzouri, A., Frick, A., Fredborg, W., & Fischer, H. (2024). Neural correlates of individual differences in multimodal emotion recognition ability. Cortex, 175, 1–11. https://doi.org/10.1016/j.cortex.2024.03.009
    • 41. Bruin, W. B., Zhutovsky, P., van Wingen, G. A., Bas-Hoogendam, J. M., Groenewold, N. A., Hilbert, K., Winkler, A. M., Zugman, A., Agosta, F., Åhs, F., Andreescu, C., Antonacci, C., Asami, T., Assaf, M., Barber, J. P., Bauer, J., Bavdekar, S. Y., Beesdo-Baum, K., Benedetti, F.,... Månsson, K. N. T… Aghajani, M. (2024). Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning. Nature Mental Health, 2(1), 104–118. https://doi.org/10.1038/s44220-023-00173-2 
    • 40. Lindahl, J., Asp, M., Ståhl, D., Tjernberg, J., Eklund, M., Björkstrand, J., van Westen, D., Jensen, J., Månsson, K. N. T., Tornberg, Å., Svensson, M., Deierborg, T., Ventorp, F., & Lindqvist, D. (2023). Add-on pramipexole for anhedonic depression: study protocol for a randomised controlled trial and open-label follow-up in Lund, Sweden. BMJ Open, 13(11), e076900. https://doi.org/10.1136/bmjopen-2023-076900 
    • 39. Xiao, S., Ebner, N. C., Manzouri, A., Li, T.-Q., Cortes, D. S., Månsson, K. N. T., & Fischer, H. (2023). Age-dependent effects of oxytocin in brain regions enriched with oxytocin receptors. Psychoneuroendocrinology, 160, 106666. https://doi.org/10.1016/j.psyneuen.2023.106666 
    • 38. Forsström, D., Lindner, P., Månsson, K. N. T., Ojala, O., Hedman-Lagerlöf, M., El Alaoui, S., Rozental, A., Lundin, J., Jangard, S., Shahnavaz, S., Sörman, K., Lundgren, T., & Jayaram-Lindström, N. (2022). Isolation and worry in relation to gambling and onset of gambling among psychiatry patients during the COVID-19 pandemic: A mediation study. Frontiers in Psychology, 13. https://doi.org/10.3389/fpsyg.2022.1045709
    • 37. Lindqvist, D., Furmark, T., Lavebratt, C., Ohlsson, L., & Månsson, K. N. T. (2022). Plasma circulating cell-free mitochondrial DNA in social anxiety disorder. Psychoneuroendocrinology, 148, 106001. https://doi.org/10.1016/j.psyneuen.2022.106001
    • 36. Jayaram-Lindström, N., Rozental, A., Sörman, K., Ojala, O., Jangard, S., El Alaoui, S., Månsson, K. N. T., Shahnavaz, S., Lundin, J., Forsström, D., Hedman-Lagerlöf, M., Lundgren, T. Mental Health in Individuals with Self-Reported Psychiatric Symptoms During the COVID-19 Pandemic: Baseline Data from a Swedish Longitudinal Cohort Study. Frontiers in Psychiatry, In press
    • 35. Olivo, G., Lövdén, M., Manzouri, A., Terlau, L., Jenner, B., Jafari, A., Petersson, S., Li, T.-Q., Fischer, H., & Månsson, K. N. T. (2022). Estimated Gray Matter Volume Rapidly Changes after a Short Motor Task. Cerebral Cortex. https://doi.org/10.1093/cercor/bhab488
    • 34. Kumar, P., Stiernborg, M., Fogdell-Hahn, A., Månsson, K. N. T., Furmark, T., Berglind, D., Melas, P. A., Forsell, Y., & Lavebratt, C. (2022). Physical exercise is associated with a reduction in plasma levels of fractalkine, TGF-β1, eotaxin-1 and IL-6 in younger adults with mobility disability. PloS One, 17(2), e0263173. https://doi.org/10.1371/journal.pone.0263173
    • 33. Li, X., Fischer, H., Manzouri, A., Månsson, K. N. T., & Li, T.-Q. (2021). A Quantitative Data-Driven Analysis Framework for Resting-State Functional Magnetic Resonance Imaging: A Study of the Impact of Adult Age. Frontiers in Neuroscience, 15, 1392. https://doi.org/10.3389/fnins.2021.768418
    • 32. Månsson, K. N. T., Waschke, L., Manzouri, A., Furmark, T., Fischer, H., & Garrett, D. D. (2022). Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2021.09.026
    • 31. Månsson, K. N. T., Lasselin, J., Karshikoff, B., Axelsson, J., Engler, H., Schedlowski, M., Benson, S., Petrovic, P., & Lekander, M. (2021). Anterior insula morphology and vulnerability to psychopathology-related symptoms in response to acute inflammation. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2021.09.007
    • 30. Hjorth, O., Frick, A., Gingnell, M., Motilla-Hoppe, J., Faria, V., Hultberg, S., Alaie, I., Månsson, K.N.T., Rosén, J., Reis, M., Wahlstedt, K., Jonasson, M., Lubberink, M., Antoni, G., Fredriksson, M., Furmark, T. Expectancy effects on serotonin and dopamine transporters during SSRI treatment of social anxiety disorder: A randomized clinical trial. Transl. Psychiatry. In press
    • 29. Koenig, J., Abler, B., Agartz, I., Åkerstedt, T., Andreassen, O. A., Anthony, M., Bär, K.-J., Bertsch, K., Brown, R. C., Brunner, R., Carnevali, L., Critchley, H. D., Cullen, K. R., de Geus, E. J. C., de la Cruz, F., Dziobek, I., Ferger, M. D., Fischer, H., Flor, H., … Månsson, K. N. T., … Quintana, D. S. (2021). Cortical thickness and resting-state cardiac function across the lifespan: A cross-sectional pooled mega-analysis. Psychophysiology, 58(7), e13688. https://doi.org/10.1111/psyp.13688
    • 28. Li, X., Fischer, H., Manzouri, A., Månsson, K. N. T., & Li, T.-Q. (2021). Dataset of whole-brain resting-state fMRI of 227 young and elderly adults acquired at 3T. Data in Brief, 38, 107333. https://doi.org/10.1016/j.dib.2021.107333
    • 27. Månsson, K. N. T., Lueken, U., & Frick, A. (2021). Enriching CBT by Neuroscience: Novel Avenues to Achieve Personalized Treatments. International Journal of Cognitive Therapy, 14(1), 182–195. https://doi.org/10.1007/s41811-020-00089-0
    • 26. Åkerstedt, T., Lekander, M., Nilsonne, G., Tamm, S., d’Onofrio, P., Kecklund, G., Fischer, H., Schwarz, J., Petrovic, P., & Månsson, K. N. T. (2020). Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults. Nature and Science of Sleep, 12, 289–298. https://doi.org/10.2147/NSS.S240493
    • 25. Bas-Hoogendam, J. M., Groenewold, N. A., Aghajani, M., Freitag, G. F., Harrewijn, A., Hilbert, K., Jahanshad, N., Thomopoulos, S. I., Thompson, P. M., Veltman, D. J., Winkler, A. M., Lueken, U., Pine, D. S., van der Wee, N. J. A., Stein, D. J., & ENIGMA-Anxiety Working Group. (2020). ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders. Human Brain Mapping, hbm.25100. https://doi.org/10.1002/hbm.25100
    • 24. Costache, M. E., Frick, A., Månsson, K. N. T., Engman, J., Faria, V., Hjorth, O., Hoppe, J. M., Gingnell, M., Frans, Ö., Björkstrand, J., Rosén, J., Alaie, I., Åhs, F., Linnman, C., Wahlstedt, K., Tillfors, M., Marteinsdottir, I., Fredrikson, M., & Furmark, T. (2020). Higher- and lower-order personality traits and cluster subtypes in social anxiety disorder. PloS One, 15(4), e0232187. https://doi.org/10.1371/journal.pone.0232187
    • 23. Kraepelien, M., Schibbye, R., Månsson, K. N. T., Sundström, C., Riggare, S., Andersson, G., Lindefors, N., Svenningsson, P., & Kaldo, V. (2020). Individually Tailored Internet-Based Cognitive-Behavioral Therapy for Daily Functioning in Patients with Parkinson’s Disease: A Randomized Controlled Trial. In Journal of Parkinson’s Disease (Vol. 10, Issue 2, pp. 653–664). https://doi.org/10.3233/jpd-191894
    • 22. Månsson, K. N. T., Cortes, D. S., Manzouri, A., Li, T.-Q., Hau, S., & Fischer, H. (2020). Viewing Pictures Triggers Rapid Morphological Enlargement in the Human Visual Cortex. Cerebral Cortex , 30(3), 851–857. https://doi.org/10.1093/cercor/bhz131
    • 21. Han, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Månsson, K. N. T., Lindqvist, D., Boks, M. P., Révész, D., Mellon, S. H., & Picard, M. (2019). Accelerating research on biological aging and mental health: Current challenges and future directions. Psychoneuroendocrinology, 106, 293–311. https://doi.org/10.1016/j.psyneuen.2019.04.004
    • 20. Hjorth, O. R., Frick, A., Gingnell, M., Hoppe, J. M., Faria, V., Hultberg, S., Alaie, I., Månsson, K. N. T., Wahlstedt, K., Jonasson, M., Lubberink, M., Antoni, G., Fredrikson, M., & Furmark, T. (2019). Expression and co-expression of serotonin and dopamine transporters in social anxiety disorder: a multitracer positron emission tomography study. Molecular Psychiatry. https://doi.org/10.1038/s41380-019-0618-7
    • 19. Månsson, K. N. T., Lindqvist, D., Yang, L. L., Svanborg, C., Isung, J., Nilsonne, G., Bergman-Nordgren, L., El Alaoui, S., Hedman-Lagerlöf, E., Kraepelien, M., Högström, J., Andersson, G., Boraxbekk, C.-J., Fischer, H., Lavebratt, C., Wolkowitz, O. M., & Furmark, T. (2019). Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. Translational Psychiatry, 9(1), 340. https://doi.org/10.1038/s41398-019-0668-2
    • 18. Rozental, A., Kottorp, A., Forsström, D., Månsson, K. N. T., Boettcher, J., Andersson, G., Furmark, T., & Carlbring, P. (2019). The Negative Effects Questionnaire: psychometric properties of an instrument for assessing negative effects in psychological treatments. Behavioural and Cognitive Psychotherapy, 47(5), 559–572. https://doi.org/10.1017/S1352465819000018
    • 17. Frick, A., & Månsson, K. N. T. (2018). Brain changes in social anxiety disorder run in the family [Review of Brain changes in social anxiety disorder run in the family]. EBioMedicine, 36, 5–6. https://doi.org/10.1016/j.ebiom.2018.09.009
    • 16. Goodwin, G. M., Holmes, E. A., Andersson, E., Browning, M., Jones, A., Lass-Hennemann, J., Månsson, K. N. T., Moessnang, C., Salemink, E., Sanchez, A., van Zutphen, L., & Visser, R. M. (2018). From neuroscience to evidence based psychological treatments - The promise and the challenge, ECNP March 2016, Nice, France. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 28(2), 317–333. https://doi.org/10.1016/j.euroneuro.2017.10.036
    • 15. Ivanov, V. Z., Enander, J., Mataix-Cols, D., Serlachius, E., Månsson, K. N. T., Andersson, G., Flygare, O., Tolin, D., & Rück, C. (2018). Enhancing group cognitive-behavioral therapy for hoarding disorder with between-session Internet-based clinician support: A feasibility study. Journal of Clinical Psychology, 74(7), 1092–1105. https://doi.org/10.1002/jclp.22589
    • 14. Lenhard, F., Sauer, S., Andersson, E., Månsson, K. N. T., Mataix-Cols, D., Rück, C., & Serlachius, E. (2018). Prediction of outcome in internet-delivered cognitive behaviour therapy for paediatric obsessive-compulsive disorder: A machine learning approach. International Journal of Methods in Psychiatric Research, 27(1). https://doi.org/10.1002/mpr.1576
    • 13. Bas-Hoogendam, J. M., van Steenbergen, H., Nienke Pannekoek, J., Fouche, J.-P., Lochner, C., Hattingh, C. J., Cremers, H. R., Furmark, T., Månsson, K. N. T., Frick, A., Engman, J., Boraxbekk, C.-J., Carlbring, P., Andersson, G., Fredrikson, M., Straube, T., Peterburs, J., Klumpp, H., Phan, K. L., … van der Wee, N. J. A. (2017). Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder. NeuroImage. Clinical, 16, 678–688. https://doi.org/10.1016/j.nicl.2017.08.001
    • 12. Faria, V., Gingnell, M., Hoppe, J. M., Hjorth, O., Alaie, I., Frick, A., Hultberg, S., Wahlstedt, K., Engman, J., Månsson, K. N. T., Carlbring, P., Andersson, G., Reis, M., Larsson, E.-M., Fredrikson, M., & Furmark, T. (2017). Do You Believe It? Verbal Suggestions Influence the Clinical and Neural Effects of Escitalopram in Social Anxiety Disorder: A Randomized Trial. EBioMedicine, 24, 179–188. https://doi.org/10.1016/j.ebiom.2017.09.031
    • 11. Månsson, K. N. T., Salami, A., Carlbring, P., Boraxbekk, C.-J., Andersson, G., & Furmark, T. (2017). Structural but not functional neuroplasticity one year after effective cognitive behaviour therapy for social anxiety disorder. Behavioural Brain Research, 318, 45–51. https://doi.org/10.1016/j.bbr.2016.11.018
    • 10. Månsson, K. N. T., Klintmalm, H., Nordqvist, R., & Andersson, G. (2017). Conventional Cognitive Behavioral Therapy Facilitated by an Internet-Based Support System: Feasibility Study at a Psychiatric Outpatient Clinic. JMIR Research Protocols, 6(8), e158. https://doi.org/10.2196/resprot.6035
    • 9. Brännström, K. J., Öberg, M., Ingo, E., Månsson, K. N. T., Andersson, G., Lunner, T., & Laplante-Lévesque, A. (2016). The initial evaluation of an Internet-based support system for audiologists and first-time hearing aid clients. Internet Interventions, 4, 82–91. https://doi.org/10.1016/j.invent.2016.01.002
    • 8. Månsson, K. N. T., Salami, A., Frick, A., Carlbring, P., Andersson, G., Furmark, T., & Boraxbekk, C.-J. (2016). Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder. Translational Psychiatry, 6, e727. https://doi.org/10.1038/tp.2015.218
    • 7. Brännström, K. J., Öberg, M., Ingo, E., Månsson, K. N. T., Andersson, G., Lunner, T., & Laplante-Lévesque, A. (2015). The Process of Developing an Internet-Based Support System for Audiologists and First-Time Hearing Aid Clients. American Journal of Audiology, 24(3), 320–324. https://doi.org/10.1044/2015_AJA-14-0094
    • 6. Månsson, K. N. T., Frick, A., Boraxbekk, C.-J., Marquand, A. F., Williams, S. C. R., Carlbring, P., Andersson, G., & Furmark, T. (2015). Predicting long-term outcome of Internet-delivered cognitive behavior therapy for social anxiety disorder using fMRI and support vector machine learning. Translational Psychiatry, 5, e530. https://doi.org/10.1038/tp.2015.22
    • 5. Nilsonne, G., Tamm, S., Månsson, K. N. T., Åkerstedt, T., & Lekander, M. (2015). Leukocyte telomere length and hippocampus volume: a meta-analysis. F1000Research, 4, 1073. https://doi.org/10.12688/f1000research.7198.1
    • 4. Tulbure, B. T., Szentagotai, A., David, O., Ștefan, S., Månsson, K. N. T., David, D., & Andersson, G. (2015). Internet-delivered cognitive-behavioral therapy for social anxiety disorder in Romania: a randomized controlled trial. PloS One, 10(5), e0123997. https://doi.org/10.1371/journal.pone.0123997
    • 3. Månsson, K. N. T., Carlbring, P., Frick, A., Engman, J., Olsson, C.-J., Bodlund, O., Furmark, T., & Andersson, G. (2013). Altered neural correlates of affective processing after internet-delivered cognitive behavior therapy for social anxiety disorder. Psychiatry Research, 214(3), 229–237. https://doi.org/10.1016/j.pscychresns.2013.08.012
    • 2. Månsson, K. N. T.,Skagius Ruiz, E., Gervind, E., Dahlin, M., & Andersson, G. (2013). Development and initial evaluation of an Internet-based support system for face-to-face cognitive behavior therapy: a proof of concept study. Journal of Medical Internet Research, 15(12), e280. https://doi.org/10.2196/jmir.3031
    • 1. Tulbure, B. T., Månsson, K. N. T., & Andersson, G. (2012). Internet treatment for social anxiety disorder in Romania: study protocol for a randomized controlled trial. Trials, 13, 202. https://doi.org/10.1186/1745-6215-13-202
  • Funding sources

    We are grateful for the generous support provided by

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    Swedish Research Council

    Funding provided 2018 and 2023 (2024-2027).

     

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    European Union

    Funding provided by the European Union (2023-2026).

     

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    KIRI Fellow

    Dr Månsson and Dr Ampatzis at Karolinska Institutet received funding from KIRI Fellow: "Investigations of brain signal variability and rapid plasticity during approach-avoidance of fear: experiments of humans and zebrafish"

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    Center for Innovative Medicine (CIMED)

    Funding provided 2022.

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    Swedish Brain Foundation

    Funding provided 2022.

     

  • Media presence

    Our research in the media:

    Scientific American

    "Cognitive-behavioral therapy improved both symptoms and markers of senescence in people with anxiety" Click here to go to the Scientific American magazine

    Forskning & Framsteg

    Rätt hjärnmönster för en lyckad terapi. En undersökning av hjärnans aktivitet avslöjar hur patienten kommer att svara på behandling med KBT. Klicka här för att läsa artikeln

    Psykologtidningen

    Biologi och psykologi i förening kan bidra till effektivare och mer individanpassad psykologisk behandling. Ladda hem artikeln här