• Things we like to do

      Moment-to-moment variability in neural response as a predictor of patients treatment outcome

      1. Månsson, K.N.T., Waschke, L., Manzouri, A., Furmark, T., Fischer, H., Garrett, D.G. (2021) Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. medRxiv, doi: https://doi.org/10.1101/2021.02.17.21251814

      Temporal dynamics in the treatment of social anxiety disorder

      1. Månsson, K.N.T., et al., (2018) Brain Before Behavior: Temporal dynamics in the treatment of social anxiety - Neural changes occur early and precede clinical improvement. Poster at the Society of Biological Psychiatry conference, New York, United States.
      2. Månsson, K. N. T., et al. (2016). Translational Psychiatry, 6:e727. doi:10.1038/tp.2015.218
      Image obtained from: PASIEKA / SCIENCE PHOTO LIBRARY / Universal Images Group

      Cellular protection and biological aging in social anxiety disordered patients receiving cognitive-behavioral therapy (CBT)

      1. Månsson, K. N. T., et al. (2019). Translational Psychiatry, 9, 340. doi.org/10.1038/s41398-019-0668-2
      Image obtained from Lindqvist et al., Neurosci Biobehav Rev doi.org/10.1016/J.NEUBIOREV.2015.05.007​

      Investigate rapid brain plasticity using structural magnetic resonance imaging

      1. Månsson, K. N. T., et al. (2019). Cerebral Cortex: doi.org/10.1093/cercor/bhz131
      This study was featured as a cover image in Cerebral Cortex, march 2020. Illustration by Staffan Lager.

      Developing an internet-based tool for clinicians

       

      1. Månsson, K. N. T., et al., (2013). Journal of Medical Internet Research., 15(12):e280. https://www.jmir.org/2013/12/e280/
      2. Brännström, K. J., [...] Månsson, K. N. T., et al. (2015). American Journal of Audiology, 24, 320-324. https://doi.org/10.1044/2015_AJA-14-0094
      3. Ivanov, V. Z., [...] Månsson, K. N. T., et al., (2018). Journal of Clinical Psychology, 1-14. https://doi.org/10.1002/jclp.22589
      4. Kraepelien, M., [...] Månsson K.N.T., et al. (2020) Journal of Parkinson's Disease, In press

    • Latest news from the lab

      Assistant Professor in medical science

      2021.02.18 Exciting times ahead! Dr Månsson is awarded a position as Assistant Professor in medical science at Karolinska Institutet (starting 2022). The position includes research funding for 6 years, click here for more information.

      Awarded the best talk at the Alpine Brain Imaging Meeting

      2020.01.16 I got an award fot the best talk at the Alpine Brain Imaging Meeting in Champéry, Switzerland. See you next year! More info, click here!

      Cellular protection after psychological treatment

      2019.12.19 New paper out! Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. The article is available for free, click here!

    • An academic dream team

      Kristoffer N T Månsson, PhD

      Principal Investigator

      Assistant professor in medical science (starting 2022)

       

      Postdoctoral fellow (2019-2021)

      • Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London
      • Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany (since Sep 2019)

      Study Director, Psychiatry Research School

      • Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (2017-2020)

      Samir El Alaoui, PhD

      Research coordinator (post doc), Centre for Psychiatry Research, Karolinska Institutet

      Dr Samir El Alaoui is a clinical psychologist with several years of clinical and research experience at the Internet Psychiatry Clinic in Stockholm, Sweden. He received his PhD in 2016 on the evaluation of internet-based CBT for social anxiety, studying its effectiveness, outcome predictors and health economics when implemented in routine psychiatric care. He has also been involved in creating Sweden’s national quality registry for internet-based psychological treatments (SibeR). Currently, Dr El Alaoui is coordinating a research project including fMRI to predict the outcome of CBT in adults with depression, insomnia or health anxiety disorder.

      Amir Manzouri, MSc

      Research engineer, Department of Psychology, Stockholm University; Centre for Psychiatry Research, Karolinska Institutet

      Amir studied medical imaging at the Royal Institute of Technology in Stockholm and have been working with neuroimaging methods as a research engineer since 2010. Amir have been involved in research on Alzheimer’s disease, gender identity, emotion, stress and anxiety disorders. Amir have extensive experience with data collection (e.g., magnetic resonance imaging, MRI scanning), and expertise in data pre- and post-processing, higher level statistical analyses on functional MRI data, e.g., psycho-physiological interactions (PPI), partial least squares (PLS), support vector machines (SVM), and independent component analysis (ICA). Moreover, Amir also have extensive expertise in structural MRI data analysis, e.g., FreeSurfer, AFNI, BrainVoyager, and voxel based morphometry (VBM), and tract-based spatial statistics (TBSS).

      Students and internships (alumni)

      Supervision (bachelor and master level)

      • Adam Yngve, Anna Stavenberg, Arian Jafari, Bo Jenner, Jennie Åberg Syed, Nils Isacsson, Örn Kolbeinsson
      • Laura Terlau, Internship (Osnabrück University, Germany); Virginia Berlose, Internship (University of Padoa, Italy)

    • Extended network and collaborations

      A selection of ongoing collaborations with principal investigators

      National collaborations

      • Andreas Frick, Uppsala University
      • Catharina Lavebratt, Karolinska Institutet
      • Daniel Lindqvist, Lunds University
      • Gerhard Andersson, Linköping University
      • Håkan Fischer, Stockholm University
      • Martin Lövdén, Gothenburg University
      • Mats Lekander, Stockholm University
      • Tie-Qiang Li, Karolinska Institutet
      • Tomas Furmark, Uppsala University
      • Viktor Kaldo, Karolinska Institutet

      International collaborations

      • Douglas D Garrett, Max Planck Institute for Human Development, Berlin, Germany 
      • Tor D Wager, Dartmouth College, NH, United States 
      • Owen Wolkowitz, University of California, San Francisco, CA, United States

    • Scientific publications

      Highlighted publications

      • Månsson, K. N. T., Cortes, D. S., Manzouri, A., Hau, S., Fischer, H. (2019) Viewing pictures triggers rapid morphological enlargement in the human visual cortex. Cerebral Cortex: https://doi.org/10.1093/cercor/bhz131
         
      • Månsson, K. N. T., Lindqvist, D., Yang, L., Svanborg, C., Isung, J., Nilsonne, G., Bergman Nordgren, L., El Alaoui, S., Hedman-Lagerlöf, E., Kraepelien, M., Högström, J., Andersson, G., Boraxbekk, CJ., Fischer, H., Lavebratt, C., Wolkowitz, O., Furmark, T. (2019) Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. Translational Psychiatry, 9, 340. https://doi.org/10.1038/s41398-019-0668-2
         
      • Månsson, K. N. T., Salami, A., Frick, A., Carlbring, P., Andersson, G., Furmark, T., Boraxbekk, C. J. (2016). Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder. Translational Psychiatry, 6:e727. https://doi:10.1038/tp.2015.218
         
      • Månsson, K. N. T., Frick, A., Boraxbekk, C. J., Marquand, A. F., Williams, S. C., Carlbring, P., Andersson, G., & Furmark, T. (2015). Predicting long-term outcome of cognitive behavior therapy for social anxiety disorder using fMRI and support vector machines. Translational Psychiatry, 5:e530. https://doi.org/10.1038/tp.2015.22
         
      • Månsson, K. N. T., Skagius Ruiz, E., Gervind, E., Dahlin, M., & Andersson, G. (2013). Development and initial evaluation of an Internet-based support system for face-to-face cognitive behavior therapy: a proof of concept study. J Med Internet Res., 15(12):e280. https://www.jmir.org/2013/12/e280/

      Preprints and articles in press

      Månsson, K.N.T., Waschke, L., Manzouri, A., Furmark, T., Fischer, H., Garrett, D.G. (2021) Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. medRxiv, doi: https://doi.org/10.1101/2021.02.17.21251814

      Peer-reviewed published articles

      27. Månsson, K.N.T., Lueken, U. & Frick, A. Enriching CBT by Neuroscience: Novel Avenues to Achieve Personalized Treatments. J Cogn Ther (2020). https://doi.org/10.1007/s41811-020-00089-0
       
      26. Koenig, J., Abler, B., Agartz, I., Åkerstedt, T., Andreassen, O. A., Anthony, M., Bär, K.-J., Bertsch, K., Brown, R. C., Brunner, R., Carnevali, L., Critchley, H. D., Cullen, K. R., de Geus, E. J. C., de la Cruz, F., Dziobek, I., Ferger, M. D., Fischer, H., Flor, H., … Månsson K.N.T., … Quintana, D. S. (2020). Cortical thickness and resting-state cardiac function across the lifespan: A cross-sectional pooled mega-analysis. Psychophysiology. https://doi.org/10.1111/psyp.13688
       
      25. Åkerstedt, T., Lekander, M., Nilsonne, G., Tamm, S., d’Onofrio, P., Kecklund, G., Fischer, H., Schwarz, J., Petrovic, P., & Månsson, K. N. T. (2020). Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults. NSS News, 12, 289–298.
       
      24. Costache, M. E., Frick, A., Månsson, K., Engman, J., Faria, V., Hjorth, O., Hoppe, J. M., Gingnell, M., Frans, Ö., Björkstrand, J., Rosén, J., Alaie, I., Åhs, F., Linnman, C., Wahlstedt, K., Tillfors, M., Marteinsdottir, I., Fredrikson, M., & Furmark, T. (2020). Higher- and lower-order personality traits and cluster subtypes in social anxiety disorder. PloS One, 15(4), e0232187.
       
      23. Kraepelien, M., Schibbye, R., Månsson K.N.T., Sundström, C., Riggare, S., Andersson, G., Lindefors, N., Svenningsson, P., & Kaldo, V. (2020) Individually tailored internet-based cognitive-behavioral therapy for daily functioning in patients with Parkinson’s disease: a randomized controlled trial. Journal of Parkinson's Disease, In press
       
      22. Månsson, K. N. T., Cortes, D. S., Manzouri, A., Li, T.-Q., Hau, S., & Fischer, H. (2020). Viewing Pictures Triggers Rapid Morphological Enlargement in the Human Visual Cortex. Cerebral Cortex , 30(3), 851–857. https://doi.org/10.1093/cercor/bhz131
       
      21. Månsson, K. N. T., Lindqvist, D., Yang, L., Svanborg, C., Isung, J., Nilsonne, G., Bergman Nordgren, L., El Alaoui, S., Hedman-Lagerlöf, E., Kraepelien, M., Högström, J., Andersson, G., Boraxbekk, CJ., Fischer, H., Lavebratt, C., Wolkowitz, O., Furmark, T. (2019) Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. Translational Psychiatry, 9, 340. https://doi.org/10.1038/s41398-019-0668-2
       
      20. Hjorth, O.R., Frick, A., Gingnell, M., Hoppe, J.M., Faria, V., Hultberg, S., Alaie, I., Månsson, K.N.T., Wahlstedt, K., Jonasson, M., Lubberink, M., Antoni, G., Fredrikson, M., Furmark, T. (2019) Expression and co-expression of serotonin and dopamine transporters in social anxiety disorder: a multitracer positron emission tomography study. Mol. Psychiatry. doi:10.1038/s41380-019-0618-7
       
      19. Han, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Månsson, K. N. T., Lindqvist, D., Boks, M. P., Révész, D., Mellon., H. S., Picard, M. (2019). Accelerating research on biological aging and mental health: Current challenges and future directions. Psychoneuroendocrinology, 106, 293–311. doi: 10.1016/j.psyneuen.2019.04.004
       
      18. Rozental, A., Kottorp, A., Forsström, D., Månsson, K., Boettcher, J., Andersson, G., Furmark, T., & Carlbring, P. (2019). The Negative Effects Questionnaire: psychometric properties of an instrument for assessing negative effects in psychological treatments. Behavioural and Cognitive Psychotherapy, 47(5), 559–572.
       
      17. Frick, A. & Månsson, K. N. T. (2018) Brain changes in social anxiety disorder run in the family. EBioMedicine, 36, 5-6, https://doi.org/10.1016/j.ebiom.2018.09.009
       
      16. Ivanov, V. Z., Enander, J., Mataix-Cols, D., Serlachius, E., Lichtenstein, P., Månsson, K. N. T., Andersson, G., Tolin, D., Flygare, O., & Rück, C. (2018). Enhancing group cognitive-behavior therapy for hoarding disorder with between-session Internet-based clinician support: a feasibility study. Journal of Clinical Psychology, 1-14. doi: 10.1002/jclp.22589
       
      15. Goodwin, G. M., Holmes, E. A., Andersson, E., Browning, M., Jones, A., Lass-Hennemann, J., Månsson, K. N. T., Moessnang, C., Salemink, E., Sanchez, A., van Zutphen, L., Visser, R. M. (2018). From neuroscience to evidence based psychological treatments - The promise and the challenge, ECNP March 2016, Nice, France. European Neuropsychopharmacology, 28(2), 317-333. doi:https://doi.org/10.1016/j.euroneuro.2017.10.036
       
      14. Lenhard, F., Sauer, S., Andersson, E., Månsson, K. N. T., Mataix-Cols, D., Ruck, C., & Serlachius, E. (2017). Prediction of outcome in internet-delivered cognitive behaviour therapy for paediatric obsessive-compulsive disorder: A machine learning approach. Int J Methods Psychiatr Res. doi:10.1002/mpr.1576
       
      13. Faria, V., Gingnell, M., Hoppe, J. M., Hjorth, O., Alaie, I., Frick, A., Hultberg, S., Wahlstedt, K., Engman, J., Månsson, K. N. T., Carlbring, P., Andersson, G., Reis, M., Larsson, E.-M., Fredrikson, M., & Furmark, T. (2017). Do You Believe It? Verbal Suggestions Influence the Clinical and Neural Effects of Escitalopram in Social Anxiety Disorder: A Randomized Trial. EBioMedicine, 24, 179-188. doi:10.1016/j.ebiom.2017.09.031
       
      12. Bas-Hoogendam, J. M., van Steenbergen, H., Nienke Pannekoek, J., Fouche, J.-P., Lochner, C., Hattingh, C. J., Cremers, H. R., Furmark, T., Månsson, K. N. T., Frick, A., Engman, J., Boraxbekk, C.-J., Carlbring, P., Andersson, G., Fredrikson, M., Straube, T., Peterburs, J., Klumpp, H., Phan, K. L., Roelofs, K., Veltman, D. J., van Tol, M.-J., Stein, D. J., & van der Wee, N. J. A. (2017). Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder. NeuroImage: Clinical, 16, 678-688. doi:10.1016/j.nicl.2017.08.001
       
      11. Månsson, K. N. T., Klintmalm, H., Nordqvist, R., & Andersson, G. (2017). Conventional cognitive behaviour therapy facilitated by an internet-based support system: a feasibility study at a psychiatric outpatient clinic. JMIR Research Protocols, 6:e158.
       
      10. Månsson, K. N. T., Salami, A., Carlbring, P., Boraxbekk, C.-J., Andersson, G., & Furmark, T. (2017). Structural but not functional neuroplasticity one year after effective cognitive behaviour therapy for social anxiety disorder. Behavioural Brain Research, 318, 45–51.
       
      9. Månsson, K. N. T., Salami, A., Frick, A., Carlbring, P., Andersson, G., Furmark, T., Boraxbekk, C. J. (2016). Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder. Translational Psychiatry, 6:e727. doi:10.1038/tp.2015.218
       
      8. Brännström, K. J., Öberg, M., Ingo, E., Månsson, K. N. T., Andersson, G., Lunner, T., & Laplante-Lévesque, A. (2016). The initial evaluation of an internet-based support system for audiologists and first-time hearing aid clients. Internet Interventions, 4, 82-91.
       
      7. Månsson, K. N. T., Frick, A., Boraxbekk, C. J., Marquand, A. F., Williams, S. C., Carlbring, P., Andersson, G., & Furmark, T. (2015). Predicting long-term outcome of cognitive behavior therapy for social anxiety disorder using fMRI and support vector machines. Translational Psychiatry, 5:e530. doi:10.1038/tp.2015.22
       
      6. Nilsonne, G., Tamm, S., Månsson, K. N. T., Åkerstedt, T., & Lekander, M. (2015). Leukocyte telomere length and hippocampus volume: a meta-analysis. F1000Research, 4:1073.
       
      5. Tulbure, B. T., Szentagotai, A., David, O., Stefan, S., Månsson, K. N. T., David, D., & Andersson, G. (2015). Internet-delivered cognitive-behavioral therapy for social anxiety disorder in Romania: a randomized controlled trial. PloS ONE, 10(5):e0123997.
       
      4. Brännström, K. J., Öberg, M., Ingo, E., Månsson, K. N. T., Andersson, G., Lunner, T., & Laplante-Lévesque, A. (2015). The process of developing an internet-based support system for audiologists and first-time hearing aid clients. American Journal of Audiology, 24, 320-324.
       
      3. Månsson, K. N. T., Carlbring, P., Frick, A., Engman, J., Olsson, C.-J., Bodlund, O., Furmark, T., & Andersson, G. (2013). Altered neural correlates of affective processing after internet-delivered cognitive behavior therapy for social anxiety disorder. Psychiatry Research, 214(3), 229-37.
       
      2. Månsson, K. N. T., Skagius Ruiz, E., Gervind, E., Dahlin, M., & Andersson, G. (2013). Development and initial evaluation of an Internet-based support system for face-to-face cognitive behavior therapy: a proof of concept study. J Med Internet Res., 15(12):e280.
       
      1. Tulbure, B. T., Månsson, K. N. T., & Andersson, G. (2012). Internet treatment for social anxiety disorder in Romania: Study protocol for a randomized controlled trial. Trials, 12:302.

    • Funding sources

      We are grateful for the generous support provided by

      Karolinska Institutet

      Funding for position as Assistant Professor in medical science at Karolinska Institutet.

      Swedish Research Agency (Vetenskapsrådet)

      International post doc, 3 year funding: "Improving psychological treatments for anxiety disorders by investigating the temporal dynamics of brain’s neural responses"

      Swedish Brain Foundation

      Funding provided 2016, 2018, and 2019, in research projects in collaboration with Professor Tomas Furmark (main applicant).

       

      All the other helpful sources

      Psykiatrifonden (2015), Carlo Perris Minnesfond and the ICCP stipend (2017, 2019), Centre for psychiatry research (2014, 2015), PRIMAs Forskningsfond (2013), Capio Forskningsstiftelse (2011, 2012).

    • Media presence

      Our research in the media:

      Scientific American

      "Cognitive-behavioral therapy improved both symptoms and markers of senescence in people with anxiety" Click here to go to the Scientific American magazine

      Forskning & Framsteg

      Rätt hjärnmönster för en lyckad terapi. En undersökning av hjärnans aktivitet avslöjar hur patienten kommer att svara på behandling med KBT. Klicka här för att läsa artikeln

      Psykologtidningen

      Biologi och psykologi i förening kan bidra till effektivare och mer individanpassad psykologisk behandling. Ladda hem artikeln här

    • Twitter

      @neuronsson

    Contact details

    Kristoffer Månsson

    E-mail

    kristoffer.mansson@ki.se

    Phone

    +46 070 580 3267

    Copyright 2020

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